Dhea 25mg Tablet 10pcs

✔️ Uses of Dhea 25mg Tablet

• Female Infertility

✔️ How does Dhea 25mg Tablet work?

DHEA is a neurosteroid that is naturally synthesized by the human body and acts on specific tissues or cells in the body.

✔️ Side Effects of Dhea 25mg Tablet

Generally well-tolerated, but observed adverse effects include mania, hypomania, acne, hirsutism, gynecomastia, testicular changes, increased blood pressure, and decreased HDL levels.

• Use caution in individuals with psychiatric disorders, diabetes, liver dysfunction, and polycystic ovarian syndrome.

✔️ Mode of Action:

• Sulfate derivative acts as a noncompetitive antagonist of GABA receptors and a positive allosteric modulator of NMDA receptors.
• Neuroprotective, antioxidant, antihypertensive, and anti-inflammatory effects are reported in humans.
• Serum DHEA levels peak 60 to 480 minutes after administration.

✔️ Infertility:

• Infertility is the failure to achieve pregnancy after 12 months or more of regular unprotected sex.
• Approximately one in every six people of reproductive age worldwide experience infertility.
• Causes of male infertility include problems in semen ejection, low sperm levels, abnormal sperm morphology, and motility.
• Female infertility causes include tubal disorders, uterine issues, ovarian disorders, and endocrine system imbalances.
• Infertility can be primary (no prior pregnancy) or secondary (at least one prior pregnancy).
• Fertility care includes prevention, diagnosis, and treatment, but access is a challenge in many countries.

Causes of Infertility:

• Female causes: tubal disorders, uterine issues, ovarian disorders, and endocrine system imbalances.
• Male causes: reproductive tract obstruction, hormonal disorders, testicular failure, and abnormal sperm function.
• Lifestyle factors like smoking, alcohol, obesity, and exposure to pollutants can affect fertility.

Diagnosis:

• Female infertility diagnosis involves pelvic exams, blood tests, ultrasounds, hysteroscopy, and laparoscopy.
• Male infertility diagnosis includes semen analysis, blood tests, and scrotal ultrasound.

Treatment:

• Lifestyle modifications, medications, surgery, and assisted reproductive technology (ART) are common treatments.
• ART includes in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), intrauterine insemination (IUI), and assisted hatching.
• Complications of treatment include a higher chance of multiples, ovarian hyperstimulation syndrome (OHSS), ectopic pregnancy, and failed cycles.

Complications:

• A higher chance of multiples, OHSS, ectopic pregnancy, and failed cycles are potential complications of infertility treatment.
• Success rates vary, but many cases can be treated, with 85-90% having successful outcomes.

Prevention:

• Prevention involves lifestyle modifications, regular health check-ups, and awareness of reproductive health.

Outlook:

• Success in treating infertility depends on the cause; lifestyle changes, medications, surgery, or ART can be effective.
• Access to fertility care remains a challenge, especially in low and middle-income countries.

Living With Infertility:

• Infertility can be emotionally challenging; support from healthcare professionals and support groups is essential.
• Treatment may involve multiple attempts, and emotional well-being is crucial during the process.

✔️ Preventing Infertility:

• Eat a well-balanced diet with a focus on essential nutrients.
• Maintain a weight that is healthy for your body type.
• Quit smoking, avoid drug misuse, and limit alcohol consumption.
• Substance abuse can negatively impact fertility.
• Get timely treatment for STIs to prevent complications that may affect fertility.
• Limit exposure to environmental toxins and pollutants.
• Be cautious of workplace or household substances that may impact reproductive health.
• Stay physically active, but avoid excessive exercise that may impact reproductive functions.
• Maintain a healthy balance to support overall well-being.
• Don't delay conception until an advanced age.
• Female fertility tends to decline with age, so early family planning may enhance the chances of conception.
• Schedule regular health check-ups to address any underlying health conditions that might impact fertility.
• Early detection and management of health issues can contribute to reproductive well-being.
• Seek advice from healthcare professionals, especially if planning pregnancy.
• Discuss family planning, fertility concerns, and potential risk factors with your healthcare provider.
• Manage stress levels and maintain emotional well-being.
• Emotional health can play a role in reproductive health.
• If there's a family history of genetic disorders, consider genetic counseling before conception.

✔️ Dosage & Administration:

• Adrenal Insufficiency: Replacement dose is 50 mg/day for 3 months; 200 mg/day achieves supraphysiological levels.
• Anorexia Nervosa: 100 mg/day for 6 months in a pilot study.
• Diminished Ovarian Reserve: 50 to 75 mg/day in divided doses in assisted reproduction.
• Exercise Training–Induced Muscle Damage: 100 mg/day over 5 days in young men undergoing exercise training.
• Major Depressive Disorder: Doses range from 30 to 450 mg/day for 6 to 8 weeks.
• Metabolic Syndrome: 100 mg/day for 3 months in a study evaluating effects against metabolic syndrome.
• Postmenopausal Women: Suggested 25 mg/day to minimize androgenic adverse effects; positive outcomes seen at doses of at least 50 mg/day.

✔️ Interaction

Supraphysiologic serum DHEAS levels can interfere with progesterone assays, leading to false-positive increases in serum progesterone.

✔️ Do not take Dehydroepiandrosterone if you have:

• Breast cancer
• Prostate cancer
• PCOS/ PCOD

✔️ Pregnancy & Lactation

Information lacking regarding safety and efficacy in pregnancy and lactation. Dhea 25 mg supplementation was evaluated for improving oocyte production in infertility.

✔️ Precautions & Warnings

• DHEA can reduce high-density cholesterol (HDL), known as good cholesterol. Caution in use for individuals with high cholesterol levels.
• Prolonged or high-dose use may increase the risk of cancers. Use only under a doctor's prescription and supervision.
• May cause urination problems in individuals with an enlarged prostate. Consult a healthcare professional if such issues arise.
• Exercise caution in individuals with heart problems, liver diseases, and blood clotting issues. Potential worsening of conditions may occur.
• DHEA may impact PCOS, causing enlarged ovaries and irregular menstrual periods. Use under guidance, especially in individuals with PCOS.

✔️ Storage Conditions

Keep below 30°C, away from light and moisture. Keep out of the reach of children.